I-275 S, Then Take The Exit For I-75 S Toward Naples/Bradenton. Stay On I-75 S For About 16 Miles. Take Exit 246 For Big Bend Road. Turn Left (East) Onto Big Bend Road. After About 1.5 Miles, Turn Right Onto Us-41 S. Go Approximately 3 Miles, Then Turn Left Onto Spindle Shell Way (This Is The Entrance To Harbour Isles).